Avaliação da aiapina e seus derivados substituídos como potenciais inibidores da enzima GST-π e determinação de seus perfis farmacocinéticos via estudos in silico
Resumo
The inhibitory activity of six coumarins against glutathione-S-transferase was investigated using molecular docking. The results indicated a great potential of these compounds to inhibit this enzyme considering interaction pattern and binding energies. Suitable pharmacokinetics properties and high drug-likeness score were in silico predicted for coumarins, although mutagenic potential was also predicted. Promising results reinforce that studies should be continued.
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Publicado
2019-07-24
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Ciências da saúde