Avaliação da umbeliferona e seus derivados substituídos como potenciais inibidores da enzima GST-π e determinação de seus perfies farmacocinéticos via estudos in silico

  • Mirnna E.C. Oliveira
  • Wagner L.C. Almeida
  • Stefânia N. Lavorato

Resumo

The inhibitory activity of coumarins against glutathione-S-transferase was assessed by molecular docking. Docking results suggest a greater inhibitory potential of compounds 3 and 6. In general, pharmacokinetic requirements were met for coumarins. However, toxicity must be improved.

Publicado
2019-07-24